A physiological study to determine the mechanism of carbon dioxide clearance during apnoea when using transnasal humidified rapid insufflation ventilatory exchange (THRIVE)

We are pleased to advise you that the research conducted by the Anaesthesia research group at Fisher and Paykel Healthcare has been published in the Anaesthesia journal.  

Several clinical studies (Patel & Nouraei 2015Gustafsson et. al. 2017Hengen et. al. 2017 and To et. al. 2017) showed that THRIVE blunts the rate of rise of CO2 in apneoic patients. This is the first paper that demonstrates how and why THRIVE clears CO2 during apneoa 

This physiological study used three laboratory airway models to investigate mechanisms of COclearance in apnoeic patients. Findings suggest that CO2 clearance during THRIVE is mediated by the interaction between supraglottic flow vortices caused by high flow and cardiogenic oscillations.  

Fisher and Paykel Healthcare values evidence-based practice to improve patient care and outcomes.  

References 

Hermez, L. A., Spence, C. J., Payton, M. J., Nouraei, S. A. R., Patel, A., & Barnes, T. H. (2019). A physiological study to determine the mechanism of carbon dioxide clearance during apnoea when using transnasal humidified rapid insufflation ventilatory exchange (THRIVE). Anaesthesia, 74(4), 441-449. 

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